Intra-epithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities

Measurement of intra-epithelial lymphocytes.

A Comparison of H&E Staining and IHC Study in Quantization of Duodenal Intra-Epithelial Lymphocytes

Rajabiani A1, Aaliepour A2, Tavangar M3, Meysamie AP4 1. Assistant Professor, Department of Pathology, Faculty of medicine, Tehran University of Medical Sciences 2. Resident, Department of Pathology, Faculty of medicine, Tehran University of Medical Sciences 3. Associate Professor, Department of Pathology, Faculty of medicine, Tehran University of Medical Sciences 4. Assistant Professor, Depar...

Quantification of Duodenal Intra-Epithelial Lymphocytes

Objective: To investigate the number of intra-epithelial lymphocytes in the duodenal mucosal biopsies of patients with non specific duodenitis, clinically labelled cases of celiac disease and in normal duodenal mucosa. Material and Methods: The study included three groups. A total of 73 duodenal biopsies received in the department of histopathology, PIMS (Pakistan Institute of Medical Sciences)...

Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production.

Immunological control of infection with cryptosporidia in mice is dependent on CD4+ T cells and the production of gamma interferon (IFN-gamma), but to date, the mucosal T cells which produce IFN-gamma local to the infection have not been characterized. We previously showed that immunity against the gastric parasite Cryptosporidium muris could be adoptively transferred to adult SCID (severe comb...

Gamma interferon production by cytotoxic T lymphocytes is required for resolution of Chlamydia trachomatis infection.

In this study, we used mice in which the gene for gamma interferon (IFN-gamma) has been disrupted (IFN-gamma-/- mice) to study the role of this cytokine in the resolution of Chlamydia trachomatis infection. We show that IFN-gamma-/- mice are impaired in the ability to clear infection with C. trachomatis compared to IFN-gamma+/+ control mice. Activated CD8(+) cytotoxic T lymphocytes (CTL) secret...